Tetrahydrokortikosteron

Tetrahydrokortikosteron

Allmän
Chem. formel	C21H34O4 _ _ _ _ _
Klassificering
Reg. CAS-nummer	68-42-8
PubChem	65553
Reg. EINECS-nummer	200-690-5
InChI	InChI=1S/C21H34O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15, 2)10-17(24)19(14)20/h12-17,19,22-24H,3-11H2,1-2H3/t12-,13-,14+,15+,16-,17+, 19-,20+,21+/m1/s1RHQQHZQUAMFINJ-DTDWNVJFSA-N
CHEBI	9481
ChemSpider	17215927
Data baseras på standardförhållanden (25 °C, 100 kPa) om inget annat anges.

Tetrahydrokortikosteron (3α,5α-tetrahydrokortikosteron, 3α,5α-TGCS) är ett endogent steroid mineralokortikoidhormon, en neurosteroid . Syntetiseras i hjärnan från 5α-dihydrokortikosteron med deltagande av enzymet 3-alfa-hydroxisteroiddehydrogenas .

Steroidhormoner (endogena)

Hepatosteroider
( lever )

(S-30: Lanostanes )	Lanosterol
(S-27: Cholestans )	Zymosterol → 7-Dehydrodesmosterol → Desmosterol → Kolesterol
Gallsyror (C-24: Cholaner )	Cholinsyra • Chenodeoxicholsyra • ‎ Deoxicholsyra • ‎ Litokolsyra • ‎ Glycocholsyra • ‎ Glycochenodeoxycholsyra • ‎ Taurocholsyra • ‎ Taurochenodeoxicholsyra

Gonadosteroider
( könskörtlar )

Gestogener (C-21: Pregnanes )	17α-AC: Epipregnenolon → Epiprogesteron → Epiallopregnandione → Epiallopregnanolon 17-AC: 17-Pregnenolon → 17-Progesteron → 17-Allopregnanedion → 17-Allopregnanolon 17β-AC: Pregnenolon → Progesteron → Allopregnanedion → Allopregnanolon
Androgener (C-19: Androstanes )	17α-OH: Epiandrostenediol → Epitestosteron → 5α-Dihydroepitestosteron → Epiandrostenediol 17-O: Dehydroepiandrosteron → Androstenedion → Androstenedion → Androsteron 17β-OH: Androstenediol → Testosteron → 5α-Dihydrotestosteron → Androstenediol
Östrogener (C-18: Estranes )	17a-OH: Epiestradiol → Epiestriol → Epiestretrol 17-O: Estron → Estradiolon → Estriolon 17β-OH: Estradiol → Estriol → Estetrol

Adrenosteroider
( binjurar )

Glumerosteroider (C-21: Pregnanes )	Mineralokortikoider 11-Deoxikortikosteron → Kortikosteron → 5α-Dihydrokortikosteron → 3α,5α-Tetrahydrokortikosteron Aldosteron → 5α-dihydroaldosteron → 3α,5α-Tetrahydroaldosteron 5α-Dihydrodeoxikortikosteron → 3α,5α-Tetrahydrodeoxikortikosteron Glukokortikoider 11-deoxikortisol → kortisol → 5a-dihydrokortisol → 3a,5a-tetrahydrokortisol Kortison → 5a-dihydrokortison → 3a,5a-tetrahydrokortison 5a-dihydrodeoxikortisol → 3a,5a-tetrahydrodeoxikortisol
Fascillosteroider (C-19: Androstanes )	lla-hydroxi 17a-OH: 11a-hydroxiepiandrostandiol → 11a-hydroxiepiandrostandiol → 5a-dihydro-11a-hydroxiepistosteron → 11a-hydroxiepiandrostandiol 17-O: 11a-hydroxydehydroepiandrosteron → 11a-hydroxiandrostenedion → 11a-hydroxiandrostenedion → 11a-hydroxiandrostenedion 17β-OH: 11α-hydroxiandrostendiol → 11α-hydroxitestosteron → 5α-dihydro-11α-hydroxitestosteron → 11α-hydroxiandrostenediol 11-keto 17a-OH: 11-ketoepiandrostandiol → 11-ketoepistosteron → 5a-dihydro-11-ketoepitestosteron → 11-ketoepiandrostandiol 17-O: 11-ketodehydroepiandrosteron → 11-ketoandrostenedion → 11-ketoandrostenedion → 11-ketoandrostenedion 17β-OH: 11-ketoandrostenediol → 11-ketotestosteron → 5a-dihydro-11-ketotestosteron → 11-ketoandrostenediol 11 p-hydroxi 17α-OH: 11β-hydroxiepiandrostanediol → 11β-hydroxiepitaestosteron → 5α-dihydro-11β-hydroxiepitaestosteron → 11β-hydroxiepiandrostanediol 17-O: 11β-hydroxydehydroepiandrosteron → 11β-hydroxiandrostenedion → 11β-hydroxiandrostenedion → 11β-hydroxiandrostenedion 17β-OH: 11β-hydroxiandrostendiol → 11β-hydroxitestosteron → 5α-dihydro-11β-hydroxitestosteron → 11β-hydroxiandrostenediol
Retikulosteroider (C-18: Estranes )	Katekol-östrogener 17a-OH: 2-hydroxiepiestradiol och 4-hydroxiepiestradiol 17-O: 2-hydroxiöstron och 4-hydroxiöstron 17p-OH: 2-hydroxiestradiol och 4-hydroxiestradiol Quinon-östrogener 17a-OH: 2,3-kinonpiestradiol och 4,3-kinonpiestradiol 17-O: 2,3-kinonestrone och 4,3-kinonestrone 17β-OH: 2,3-kinonestradiol och 4,3-kinonestradiol
Medullosteroider	2,3-OH DOPA → Dopamin → Noradrenalin → Adrenalin 3-OH Tryptofan → 5-hydroxitryptofan → Serotonin → N-acetyl-5-hydroxitryptamin → Melatonin 3,4-OH DOPA → Dopamin → Noradrenalin → Adrenalin